Table 2.
Association of MRS measures with age, sex, and tissue voxel composition
| Overall model statistics | Univariate p values and statistics | |||||
|---|---|---|---|---|---|---|
| Metabolite (degrees of freedom) | Adjusted R2 | F | p Value | Age | Sex | %Gray matter/tissue |
| GABA+/Cre (3,224) | 0.07 | 6.9 | 0.0002 | 0.00001; β = −0.29 (−0.42/−0.16); η2 = 0.08 | 0.63 | 0.98 |
| NAA/Cre (3,225) | 0.12 | 11.3 | 0.000001 | 0.0000001; β = −0.33 (−0.45/−0.21); η2 = 0.11 | 0.15 | 0.09 |
| Cho/Cre (3,225) | 0.16 | 15 | 0.0000001 | 0.22; β = 0.07 (−0.05/0.19); η2 = 0.007 | 0.000001; M > F; η2 = 0.14 | 0.004; β = −0.19 |
| Glx/Cre (3,225) | 0.14 | 13.2 | 0.000001 | 0.000003; β = −0.3 (−0.42/−0.17); η2 = 0.09 | 0.00009; M > F; η2 = 0.07 | 0.91 |
The table provides the results of the overall regression models (R2, F, and p value) and the p values for the univariate results for each independent variable of interest. Where significant overall and univariate tests occurred, a beta value is reported in order to establish the directionality of the finding and a partial eta squared to provide a measure of effect size. Significant effects beyond multiple comparison correction are in bold
NA not applicable, CSF cerebrospinal fluid, NAA N-acetyl-aspartate, Glx glutamate + glutamine, Cho choline, Cre creatine