Table 3.
White matter tracts showing significantly lower FA in OBP and/or OCP vs OHP
| k | F | P-value (FDR corrected) | |
|---|---|---|---|
| Forceps minora | |||
| Level-1 analyses (OBP, OCP, OHP) | 7 | 7.6 | 0.020 |
| Level-2 analyses (OBP, OHP) | 6 | 6.8 | 0.030 |
| Level-2 analyses (OCP, OHP) | 7 | 13.6 | 0.002 |
| Level-3 analyses (healthy OBP, OHP) | 4 | 5.6 | 0.049 |
| Level-3 analyses (healthy OCP, OHP) | 7 | 6.9 | 0.038 |
| Level-3 analyses (affected OBP, OHP) | — | — | — |
| Level-3 analyses (affected OCP, OHP) | 7 | 10.4 | 0.011 |
| Left cingulum bundlea | |||
| Level-1 analyses (OBP, OCP, OHP) | 28 | 16.7 | 0.009 |
| Level-2 analyses (OBP, OHP) | 26 | 16.7 | 0.011 |
| Level-2 analyses (OCP, OHP) | 28 | 29.3 | 0.001 |
| Level-3 analyses (healthy OBP, OHP) | 25 | 9.7 | 0.035 |
| Level-3 analyses (healthy OCP, OHP) | 28 | 20.0 | 0.002 |
| Level-3 analyses (affected OBP, OHP) | 16 | 18.7 | 0.034 |
| Level-3 analyses (affected OCP, OHP) | 27 | 14.4 | 0.008 |
| Left inferior longitudinal fasciculusb | |||
| Level-1 analyses (OBP, OCP, OHP) | 8 | 8.6 | 0.024 |
| Level-2 analyses (OBP, OHP) | 8 | 11.5 | 0.004 |
| Level-2 analyses (OCP, OHP) | 7 | 7.9 | 0.02 |
| Level-3 analyses (healthy OBP, OHP) | 3 | 6.0 | 0.046 |
| Level-3 analyses (healthy OCP, OHP) | — | — | — |
| Level-3 analyses (affected OBP, OHP) | 7 | 8.1 | 0.021 |
| Level-3 analyses (affected OCP, OHP) | 5 | 9.2 | 0.015 |
| Right superior longitudinal fasciculus | |||
| Level-1 analyses (OBP, OCP, OHP) | 2 | 8.6 | <0.001 |
| Level-2 analyses (OBP, OHP) | 2 | 8.9 | 0.008 |
| Level-2 analyses (OCP, OHP) | — | — | — |
| Level-3 analyses (healthy OBP, OHP) | 2 | 7.0 | 0.034 |
| Level-3 analyses (affected OBP, OHP) | — | — | — |
| White matter tracts showing significant greater FA in OBP and/or OCP vs OHP | |||
|---|---|---|---|
| Right inferior longitudinal fasciculus | |||
| Level-1 analyses (OBP, OCP, OHP) | 6 | 8.2 | 0.012 |
| Level-2 analyses (OBP, OHP) | 6 | 9.6 | 0.007 |
| Level-2 analyses (OCP, OHP) | 6 | 14 | 0.003 |
| Level-3 analyses (healthy OBP, OHP) | 3 | 4.2 | 0.050 |
| Level-3 analyses (healthy OCP, OHP) | 6 | 13.7 | 0.014 |
| Level-3 analyses (affected OBP, OHP) | 5 | 12.2 | 0.016 |
| Level-3 analyses (affected OCP, OHP) | 2 | 6.5 | 0.035 |
| Right uncinate fasciculus | |||
| Level-1 analyses (OBP, OCP, OHP) | 3 | 9 | 0.004 |
| Level-2 analyses (OBP, OHP) | 3 | 9.8 | 0.008 |
| Level-2 analyses (OCP, OHP) | 3 | 8.6 | 0.005 |
| Level-3 analyses (healthy OBP, OHP) | 2 | 7.2 | 0.034 |
| Level-3 analyses (healthy OCP, OHP) | 2 | 8.4 | 0.022 |
| Level-3 analyses (affected OBP, OHP) | — | — | — |
| Level-3 analyses (affected OCP, OHP) | 3 | 6.4 | 0.038 |
Age, age2, and sex were covariates in all analyses
OBP offspring of bipolar parents, OCP offspring of comparison parents, OHP offspring of healthy parents
aLower FA was associated with significantly lower AD in healthy OBP, affected OBP, healthy OCP, and affected OCP (all FDR corrected p < 0.05)
bLower FA was associated with significant lower AD in healthy OBP, affected OBP, and healthy OCP