Table 3.

Estimated marginal means from mixed effect model for cognitive functioning assessments

	Timepoint–mean (SE)
Variable	Baseline	Week 4	|∆ Baseline–week 4 active vs sham| (95% CI)
RBANS–total a
Active	−0.9 (0.2)	−0.4 (0.2)	0.0 (−0.3 to 0.3)
Sham	−0.8 (0.2)	−0.3 (0.2)
RBANS–immediate memory a
Active	−0.8 (0.3)	−0.1 (0.3)	0.2 (−0.8 to 0.3)
Sham	−0.7 (0.2)	−0.3 (0.3)
RBANS–visuospatial a
Active	−0.4 (0.3)	−0.1 (0.3)	0.3 (−0.9 to 0.2)
Sham	0.3 (0.3)	0.3 (0.3)
RBANS–language a
Active	−0.6 (0.1)	−0.4 (0.1)	0.2 (−0.2 to 0.7)
Sham	−0.8 (0.1)	−0.4 (0.1)
RBANS–attention a
Active	−0.7 (0.2)	−0.5 (0.2)	0.2 (−0.7 to 0.2)
Sham	−0.9 (0.2)	−0.9 (0.2)
RBANS–delayed memory a
Active	−0.8 (0.2)	−0.2 (0.2)	0.2 (−0.2 to 0.6)
Sham	−0.7 (0.2)	0.1 (0.2)
RBANS–codinga
Active	−0.6 (0.2)	−0.5 (0.2)	0.1 (−0.4 to 0.2)
Sham	−0.5 (0.1)	−0.4 (0.2)
RBANS–semantic fluency
Active	19.8 (0.8)	19.0 (0.9)	0.7 (−1.8 to 3.2)
Sham	18.8 (0.8)	18.7 (0.8)
DKEFS-CWI condition 3 b
Active	10.2 (0.5)	11.0 (0.6)	0.0 (−1.1 to 1.2)
Sham	10.5 (0.5)	11.4 (0.5)
DKEFS-CWI condition 4 c
Active	11.2 (0.6)	11.3 (0.6)	0.2 (−1.6 to 1.1)
Sham	11.4 (0.5)	11.3 (0.5)
DKEFS-TMT
Active	8.6 (0.7)	9.0 (0.8)	0.1 (−2.2 to 2.0)
Sham	9.4 (0.7)	9.7 (0.7)

Fixed effects included in model were treatment allocation, time, and treatment × time interaction and participant identifiers were a random effect (random intercept)

RBANS Repeatable Battery for the Assessment of Neuropsychological Status, DKEFS Delis–Kaplan Executive Function System, CWI Color Word Interference, TMT Trail Making Test, SE standard error, CI confidence interval, ∆ change in symptoms

^aZ-score calculated based on test mean and standard deviation to account for differences between test versions; ²Test score weighted based on inhibition; ³Test score weighted based on switching

^bTest score weighted based on inhibition

^cTest score weighted based on switching