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. 2018 Sep 12;8:13654. doi: 10.1038/s41598-018-31856-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the chimeric SAT2/O recombinant FMDV genome, encoding the VP4 inner-capsid structural protein and Lpro (Lab and Lb forms), 2B, 2C, 3A, 3B, 3C and 3D non-structural proteins of FMDV O1K (white boxes) in combination with the outer capsid proteins (VP2, VP3 and VP1) and the non-structural 2A product of SAT2 Zim/7/83 (grey boxes). The 5′UTR, 3′ UTR and poly (A) tail are also depicted.