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. 2018 Sep 12;8:13675. doi: 10.1038/s41598-018-32042-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of postnatal L-368,899 treatment on behavior in adult mice. (a) Total distance in OF test. There was no significant difference in the total distance traveled among groups (one-way ANOVA: F_3,47 = 2.488, p = 0.072; Dunnett’s test). (b) Time spent in the center area in the OF test. There was no significant difference in the center time among groups. (one-way ANOVA: F_3,47 = 3.418, p = 0.025; Steel’s test) (c) Time taken to approach to the stranger cage (S) and the empty cage (C) in 3-CSI test. Under the treatment with L-368,899, WT or 8OH-DPAT-treated 15q dup mice showed no significant difference between the time spent around the stranger mouse and the empty cage (WT-saline: t₁₁ = 3.937, p = 0.002, Cohen’s d = 1.96; WT-L368899: t₁₂ = 0.623, p = 0.545, Cohen’s d = 0.31; WT-DPAT-L368899: t₁₃ = 2.948, p = 0.011, Cohen’s d = 1.50; 15q dup-DPAT-L368899: t₁₁ = 1.805, p = 0.098, Cohen’s d = 0.80; paired t-test). The numbers of mice tested and their litters (mice/litters) in each group are as follows. WT-saline (12/5), WT-L368899 (13/4), WT-DPAT-L368899 (14/4), 15q dup-DPAT-L368899 (12/4). Data represent the mean ± SEM. *p < 0.05, **p < 0.01.