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. 2018 Sep 12;8:13713. doi: 10.1038/s41598-018-32054-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HIF2α stabilization causes pancreatic abnormalities reminiscent of pancreatitis. Gomori trichome staining reveals increased connective tissue (stained in blue) in Pdx1-Cre;HIF2dPA pancreata (B) compared to control pancreata (A) at 8 weeks of age. Increase in smooth muscle actin (SMA) positive cells (white arrowhead) in Pdx1-Cre;HIF2dPA pancreata (D) compared to control pancreata (C) at 8 weeks of age. Ducts are marked by staining with lectin Dolichos biflorus agglutinin (DBA). Increase of the mesenchymal marker vimentin in Pdx1-Cre;HIF2dPA pancreata (F, black arrowheads) at 8 weeks of age. Only a few scattered cells are positive for vimentin in control pancreata (E, black arrowhead). (G) Quantification of vimentin-positive area per total pancreatic area. CD11b immunohistochemistry in control (H) and Pdx1-Cre;HIF2dPA pancreata (I, black arrowheads) at eight weeks of age. (J) Quantification of CD11b-positive cells per field. F4/80 immunohistochemistry in control (K) and Pdx1-Cre;HIF2dPA pancreata (L, black arrowheads) at eight weeks of age. (M) Quantification of F4/80-positive cells per field. Data points represent values for each individual mouse. The mean value is indicated as a horizontal line. Scale bars = 50 µm. **P < 0.01; ***P < 0.001.