Figure 3.

Molecular mechanism of SRA action. SRA exerts its diverse biological functions and roles in the development of cancers and other diseases through interacting with protein partners in both activating and repressive complexes. SRA also regulates the activity of transcription factors including nuclear receptors (NRs), MyoD, Oct4, and FOXO1; coregulators; and components of chromatin modification factors. PUS, pseudouridine synthase; RISC, RNA-induced silencing complex; Trxn, trithorax complex; SHARP, the SMRT/HDAC1 associated repressor protein; SLIRP, SRA stem-loop interacting RNA binding protein; CTCF, CCCTC-binding factor; HP1γ, heterochromatin protein 1γ; and LSD1, lysine-specific demethylase 1; PRC2, polycomb repressive complex 2.