Table 2.
DTI metrics distribution in the White Matter in FRDA and HCs and the intergroup variation.
| TRACTS | Mean FA [μm2/s] | Mean MD [μm2/s] | Mean AD [μm2/s] | Mean RD [μm2/s] | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC | FRDA | Variation % | HC | FRDA | Variation % | HC | FRDA | Variation % | HC | FRDA | Variation % | |
| SCP L | 0.537 | 0.349 | −34.9 | 3.065 | 4.400 | 43.6 | 1.667 | 1.958 | 17.4 | 0.699 | 1.221 | 74.7 |
| SCP R | 0.550 | 0.369 | −33.0 | 2.984 | 4.099 | 37.4 | 1.646 | 1.865 | 13.3 | 0.669 | 1.117 | 66.9 |
| ICP R | 0.501 | 0.390 | −22.2 | 2.164 | 2.607 | 20.5 | . | . | . | 0.505 | 0.682 | 35.0 |
| ICP L | 0.497 | 0.395 | −20.5 | 2.190 | 2.605 | 19.0 | . | . | . | 0.514 | 0.679 | 32.2 |
| Forceps major | 0.506 | 0.447 | −11.8 | 2.496 | 2.786 | 11.6 | . | . | . | 0.570 | 0.682 | 19.6 |
| Body of CC | 0.627 | 0.574 | −8.6 | . | . | . | . | . | . | 0.447 | 0.552 | 23.6 |
| Posterior thalamic radiation L | 0.560 | 0.515 | −8.0 | 2.209 | 2.407 | 9.0 | . | . | . | 0.480 | 0.557 | 16.1 |
| CST R | 0.510 | 0.467 | −8.5 | 2.187 | 2.356 | 7.7 | . | . | . | 0.509 | 0.575 | 13.0 |
| Posterior thalamic radiation R | 0.561 | 0.517 | −7.8 | 2.165 | 2.363 | 9.1 | . | . | . | 0.469 | 0.543 | 15.8 |
| MCP and pontine crossing tract | 0.490 | 0.453 | −7.5 | 2.066 | 2.289 | 10.8 | 1.087 | 1.157 | 6.5 | 0.490 | 0.566 | 15.6 |
| CST L | 0.516 | 0.478 | −7.4 | . | . | . | . | . | . | 0.496 | 0.551 | 11.2 |
| Splenium of CC | 0.654 | 0.614 | −6.1 | 2.453 | 2.703 | 10.2 | . | . | . | 0.465 | 0.553 | 18.9 |
GLM p < = 0.05 Bonferroni on FA. FA, Fractional anisotropy; MD: medial diffusivity; RD, radial diffusivity; HCs, healthy controls, FRDA, Friedreich's ataxia patients; SCP, superior cerebellar peduncle; L, left; R, right; ICP, inferior cerebellar peduncle; MCP medial cerebellar peduncle; CC, corpus callosum; CST, cortical spinal tract.