Table 4.

Correlations between fMRI activation and clinical covariates.

	AAO (β)	GAAsr (β)	ICARS (β)	SARA (β)	FARSne (β)	DD (β)
RIGHT-HAND TASK
Motor Cortex L	1.0139*	–	–	–	–	–
Middle temporal lobe	0.8804*	−0.622	−0.460	−0.465	−0.516	–
Insula L	1.0634*	−0.647	−0.671	−0.599	−0.620	–
Posterior Cingulum R	0.858	–	–	–	–	–
Cuneus R	0.904	–	–	–	–	–
Cerebellar anterior lobe (lobules V–VI) R	0.9486*	–	−0.602	–	–	–
LEFT-HAND TASK
SMA R	–	–	–	–	–	−0.540
Cerebellar anterior lobe (lobules V–VI) R	0.9598*	−0.739	−0.648	−0.625	−0.587	–
Cerebellar posterior lobe (lobules VII–VIII) L	0.744	−0.758	−0.605	−0.647	−0.586	–

p < 0.05;

^*p < 0.05/nr of covariates. SMA, supplementary motor area; L, left; R, right; AAO, age at onset; DD, disease duration; GAAsr, GAA short-allele; SARA, Scale for the Assessment and Rating of Ataxia (0–40); ICARS, International Cooperative Ataxia Rating Scale (0–100); FARS-ne, Friedreich Ataxia Rating Scale -neurological examination (0–117).