Table 1. Baseline Demographics and Disease Characteristics (Full Analysis Set).

Characteristic	IAI Plus Sham PDT (n = 157)	IAI Plus Active PDT (n = 161)
Sex, No. (%)
Male	110 (70.1)	112 (69.6)
Female	47 (29.9)	49 (30.4)
Race, No. (%)
Asian	145 (92.4)	151 (93.8)
Non-Asian	12 (7.6)	10 (6.2)
Ethnicity, country, No. (%)
Japanese	75 (47.8)	77 (47.8)
Non-Japanese	82 (52.2)	84 (52.2)
Age, mean (SD), y	70.8 (8.4)	70.4 (8.0)
Disease duration, median, mo	0.49a	0.39
Baseline BCVA score, mean (SD)	57.7 (11.3)	59.0 (11.5)
Total NEI VFQ-25 score at baseline, mean (SD)	79.0 (11.5)	75.4 (14.6)
Mean CST at baseline, mean (SD)	347.8b (118.9)	346.1c (117.5)
Type of CNV lesions at screening, No. (%)
CNV < 50% of lesion	22 (14.0)	19 (11.8)
CNV > 50% of lesion
Predominantly classic	23 (14.6)	13 (8.1)
Minimally classic/occult	112 (71.3)	129 (80.1)
Total lesion size at baseline, mean (SD), mm2	8.13 (7.89)	7.91 (6.67)
CNV size at baseline, mean (SD), mm2	6.06 (6.28)	5.86 (5.06)d
Presence of polypoidal lesions, detected with ICGA, No. (%)	139 (88.5)	143 (88.8)
Presence of branch vessel network, No. (%)	122 (77.7)	138 (85.7)
Presence of serous/hemorrhagic PED, No. (%)	78 (49.7)	70 (43.8)
Smoking history, No. (%)
Never	64 (40.8)	73 (45.3)
Former	67 (42.7)	65 (40.4)
Current	26 (16.6)	23 (14.3)
Qualified for rescue therapy at week 12, No. (%)
Rescue therapy	8 (5.1)	11 (6.8)
Nonrescue therapy	149 (94.9)	150 (93.2)

Abbreviations: BCVA, best-corrected visual acuity; CNV, choroidal neovascularization; CRT, central retinal thickness; CST, central subfield thickness; IAI, intravitreal aflibercept injection; ICGA, indocyanine green angiography; NEI VFQ-25, 25-item National Eye Institute Visual Function Questionnaire; PDT, photodynamic therapy; PED, pigment epithelial detachment.

^a n = 156.

^b n = 152.

^c n = 158.

^d n = 160.