Table 1. . Large series of spinal stereotactic body radiotherapy and reported fracture incidence.
| Study (year) | FU (months) | Dose; Gy (mean) | Isodose (%) | BED3 (Gy) | Patients (n) | Lesions (n) | Fractures; n (%) | Notes | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| Boehling et al.(2012) | 14.9 | 1 × 18 3 × 9 5 × 6 |
– | 126 108 90 |
93 | 123 | 25 (20%) | – | [43] |
| Cunha et al. (2012) | 7.4 | 1 × 24 to 5 × 7 | – | 216 116 |
90 | 167 | 19 (11%) | Median time to fracture: 2 months; unstable patients were excluded | [45] |
| Rose et al. (2009) | 13 | 1 × 18 to 1 × 24 | 100 | 124–216 | 62 | 71 | 27 (39%) | Lytic lesions and 40% involvement were risk factors | [44] |
| Gagnon et al. (2009) | 12 | 3 × 7–8 5 × 7.5 |
75 | 88 131 |
200 | 274 | 2 | – | [46] |
| Yamada et al. (2008) | 15 | 1 × 18–24 (24) | 100 | – | 93 | 103 | 2 | – | [19] |
| Chang et al. (2007) | 21.3 | 5 × 6 3 × 9 |
– | 90 108 |
63 | 74 | NR | Excluded unstable spine | [62] |
| Degen et al. (2005) | 12 | (3.6) × (6.45) | 70 | 73 | 51 | 72 | NR | – | [63] |
| Dodd et al. (2006) | 23 | 1 × (19.6) | 80 | 148 | 51 | 55 | NR | – | [64] |
| Gertszen et al. (2007) | 21 | 12.5–25 | 80 | – | 393 | 500 | NR | Excluded unstable spine | [27] |
| Gertszen et al. (2004) | 18 | 1 × 12–20 (14) | – | 80 | 115 | 125 | NR | – | [65] |
BED3: Bioequivalent dose; FU: Follow-up; NR: Not reported.