Table 1.
Serum biochemistry and urinalysis from TDF initiation to 14 months post switch to TAF.
| Initiation of TDF | 12 months post TDF | Admission (28 months post TDF) | 10 months post TAF | 14 months post TAF | Normal values | |
|---|---|---|---|---|---|---|
| Sodium, mmol/l | 132 | 130 | 137 | 138 | 138 | 137–146 |
| Potassium, mmol/l | 4.7 | 3.7 | 2.9 | 3.7 | 4.8 | 3.5–5.2 |
| Bicarbonate, mmol/l | 26 | 23 | 17 | 26 | 26 | 22–32 |
| Creatinine, μmol/l | 42 | 66 | 161 | 108 | 106 | 60–120 |
| eGFR, ml/min/1.73 m2 | >90 | >90 | 41 | 65 | 67 | >60 |
| Phosphate, mmol/l | 1.40 | 0.37 | 0.29 | 0.72 | 1.08 | 0.70–1.40 |
| Random glucose, mmol/l | – | – | 5.2 | 4.6 | 4.6 | 3.0–7.8 |
| Urine glucose | Nil | 4+ | 4+ | – | Nil | Nil |
| Urine protein | Nil | 3+ | 3+ | – | 1+ | Nil |
| Urine casts | Nil | Nil | 1+ | – | Nil | Nil |
| Urine phosphate concentration, mmol/l | – | – | 32.3 | – | 9.4 | – |
| Urine protein concentration, g/l | – | – | 2.04 | – | 0.32 | 0.00–0.10 |
eGFR, estimated glomerular filtration rate; TAF, tenofovir alafenamide fumarate; TDF, tenofovir disoproxil fumarate. (Bold text- abnormal result)