Table 1.

Direct and indirect transcriptional targets of NME1 and NME2

NME isoform	Gene target	DNA-binding target	Interacting protein(s)	Mechanism	Regulation	Ref.
1	PDGFA	NHE Promoter, 5′-SHS silencer	-	Direct	Activation, repression	23,24,39,40
1	TP53	Promoter	-	Direct	Activation	66
1	MMP2	Promoter	Blocks YB-1	Direct	Repression	41
1	CCND1	Promoter AP1 element	AP1	Indirect	Repression	46
1	CTSD BCL2 CCND1	ERE	Enhances ERα–ERE interaction	Indirect	Suppresses ERE activity	47,48
2	CMYC	NHEIII1 Promoter	CNBP	Direct	Activation	16,19,34–36,45
2	PDGFA	NHE promoter, 5′-SHS silencer	-	Direct	Activation, repression	23,24,39,40
2	VCL	Promoter		Direct	Repression	43
2	CTSD BCL2 CCND1	ERE	ERβ	Indirect	Enhances ERE activity	47,48
2	PTGS2	NF-κB, CREB, AP1 motifs	NF-κB, CREB, AP1 via EBNA3C	Indirect	Activation	7
2	MMP9	NF-κB, AP1 motifs	NF-κB, AP1 via EBNA3C	Indirect	Activation	67
2	ITGAV	GATA-1, SP1 motifs	GATA-1, SP1 via EBNA3C	Indirect	Activation	50
2	ITGAV	GATA-1 motifs	GATA-1 alone	Indirect	Repression	50