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. Author manuscript; available in PMC: 2019 Mar 6.
Published in final edited form as: Neurosci Lett. 2018 Feb 3;668:147–153. doi: 10.1016/j.neulet.2018.01.024

Figure 1. Genetic deletion of NMDARs in layer 2-3 pyramidal neurons in motor cortex.

Figure 1.

(A) Schematic of in utero electroporation of Cre-mCherry performed at E14.5 GRIN1f/f embryos.

(B)Expression of Cre-mCherry in layer 2/3 pyramidal neurons in Grin1f/f primary motor cortex.

(C)Dual recordings showed that Cre expression led to loss of NMDA EPSCs in layer 2/3 pyramidal neurons in cortical slices made from P13-P17 mice (Control (Cnt), 110.9 ± 20.5 pA, n = 6; Cre, 0.80 ± 0.32 pA, n = 6; p < 0.01; paired t-test). Scale bar: 50 pA and 50 ms.