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. Author manuscript; available in PMC: 2019 Mar 6.
Published in final edited form as: Neurosci Lett. 2018 Feb 3;668:147–153. doi: 10.1016/j.neulet.2018.01.024

Figure 4. GABAergic synapse development in cortical neurons and in VTA dopamine neurons requires NMDARs.

Figure 4.

(A-B) mIPSC frequency was strongly reduced in Cre-positive VTA dopamine neurons from Grin1f/f/DAT-Cre/tdTomatoCremice (Frequency: Grin1f/+ (1.59 ± 0.20 Hz, n = 21), Grin1f/f (0.61 ± 0.08 Hz, n = 22), p < 0.001, t-test; Amplitude: Grin1f/+ (−20.84 ± 0.79 pA, n = 21), Grin1f/f (−21.62 ± 1.26 pA, n = 22), p = 0.61, t-test). Cumulative distributions were compared by the Kolmogorov-Smirnov test (p ≥ 0.05 for amplitude and p < 0.001 for interevent interval). Scale bar: 20 pA and 1s.