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The effect of ionizing radiation on tumor-associated macrophages (TAMs). Depending on a multitude of factors, including dose, genetics and age, ionizing radiation may either promote a pro-inflammatory M1 like response or an anti-inflammatory M2 like response in tumor-associated macrophages (TAMs). As a result, TAMs may either promote or inhibit anti-tumor responses thus making the tumor sensitive or resistant to radiotherapy, respectively. Figure kindly provided by Wu et al. [1].
