Table 4.
Demographic and clinical factors associated with attrition during ART Care in children (aged 18 months – < 15 years) enrolled under IHC Program between Jan 2005 – June 2016 (n = 2330).
| Patient’s characteristics | Number | Attrition (N) |
Attrition rate per 100 persons-year follow-up (95% CI) | Unadjusted hazard ratio (95%CI) | Adjusted hazard ratio (95%CI) | P value |
|---|---|---|---|---|---|---|
| Total | 2330 | 316 | 3.8 (3.4–4.3) | |||
| Gender | ||||||
| Male | 1233 | 178 | 4.2 (3.6–4.8) | ref | ref | |
| Female | 1097 | 138 | 3.4 (2.9–4.1) | 0.9 (0.7–1.1) | 0.8 (0.6–1.0) | 0.050 |
| Age | ||||||
| 18 months to < 5 years | 683 | 80 | 3.2 (2.6–4.0) | ref | ref | |
| 5 years to < 10 years | 1016 | 131 | 3.5 (2.9–4.1) | 1.1 (0.8–1.4) | 0.9 (0.7–1.4) | 0.919 |
| 10 years to < 15 years | 631 | 105 | 5.2 (4.3–6.3) | 1.5 (1.1–2.0) | 1.2 (0.8–1.7) | 0.347 |
| Growtha | ||||||
| Normal | 367 | 28 | 2.1 (1.5–3.1) | ref | ref | |
| Underweight | 1819 | 242 | 3.7 (3.2–4.1) | 1.7 (1.2–2.5) | 1.3 (0.8–2.0) | 0.253 |
| Overweight | 96 | 9 | 2.6 (1.4–5.1) | 1.2 (0.6–2.6) | 0.8 (0.4–1.9) | 0.670 |
| Unknown | 48 | 37 | 62.6 (45.3–86.4) | 19.4 (11.9–31.8) | 11.8 (6.5–21.3) | <0.001 |
| Haemoglobin (baseline) | ||||||
| No anaemia | 506 | 41 | 2.2 (1.6–3.0) | ref | ref | |
| Mild | 405 | 35 | 2.4 (1.7–3.3) | 1.1 (0.7–1.7) | 1.1 (0.7–1.7) | 0.672 |
| Moderate | 1146 | 162 | 3.8 (3.3–4.5) | 1.7 (1.2–2.4) | 1.6 (1.1–2.2) | 0.014 |
| Severe | 193 | 50 | 8.3 (6.3–10.9) | 3.5 (2.3–5.3) | 2.5 (1.6–3.8) | <0.001 |
| Unknown | 80 | 28 | 20.3 (14.0–29.4) | 6.4 (3.9–10.4) | 1.5 (0.8–2.9) | 0.252 |
| WHO stage (baseline) | ||||||
| Stage 1 | 570 | 40 | 2.3 (1.7–3.2) | ref | ref | |
| Stage 2 | 516 | 39 | 2.1 (1.6–2.9) | 0.9 (0.6–1.6) | 0.9 (0.6–1.5) | 0.899 |
| Stage 3 | 1082 | 185 | 4.3 (3.7–4.9) | 2.2 (1.5–3.1) | 1.7 (1.2–2.5) | 0.003 |
| Stage 4 | 156 | 47 | 10.4 (7.8–13.8) | 4.6 (2.9–6.9) | 3.2 (2.0–5.1) | <0.001 |
| Unknown | 6 | 5 | 139.2 (57.9–334.4) | 25.4 (10.0–64.6) | 1.4 (0.5–4.1) | 0.559 |
| Immunological staging (CD4 count/cd4%) | ||||||
| No | 549 | 29 | 1,6 (1.1–2.3) | ref | ref | |
| Mild | 288 | 24 | 2.4 (1.6–3.5) | 1.5 (0.9–2.6) | 1.4 (0.8–2.4) | 0.236 |
| Advance | 398 | 47 | 3.3 (2.5–4.4) | 2.1 (1.3–3.4) | 1.8 (1.1–2.9) | 0.015 |
| Severe | 939 | 167 | 4.6 (3.9–5.4) | 3.2 (2.1–4.7) | 2.2 (1.5–3.3) | <0.001 |
| Unknown | 156 | 49 | 11.5 (8.7–15.3) | 6.9 (4.3–10.9) | 3.9 (2.3–7.0) | <0.001 |
| Hepatitis B infection(baseline) | ||||||
| Negative | 2185 | 271 | 3.4 (3.0–3.9) | ref | ref | |
| Positive | 59 | 6 | 2.6 (1.1–5.7) | 0.8 (0.3–1.8) | 0.6 (0.3–1.3) | 0.176 |
| Unknown | 86 | 39 | 29.2 (21.3–39.9) | 5.7 (4.1–7.9) | 5.3 (3.6–7.7) | <0.001 |
| Previous TB history | ||||||
| Absent | 1570 | 174 | 3.0 (2.6–3.5) | ref | ref | |
| Present | 760 | 142 | 5.6 (4.7–6.5) | 1.8 (1.4–2.2) | 1.3 (1.0–1.6) | 0.022 |
aWeight-for-age Z-score or BMI