Table 4.
Compound number | Single-stranded substrate |
Double-stranded substrate |
||
---|---|---|---|---|
Inhibition constant, KI, µM | Type of inhibition | Inhibition constant, KI, µM | Type of inhibition | |
4 | 0.3 ± 0.1 | Mixed | 0.2 ± 0.1 | Mixed |
6 | 7.9 ± 0.8 | Noncompetitive | 8.8 ± 0.9 | Noncompetitive |
7 | 0.9 ± 0.3 | Mixed | 0.3 ± 0.1 | Mixed |
10 | 1.7 ± 0.4 | Mixed | 3.1 ± 0.3 | Mixed |
11 | 0.2 ± 0.1 | Mixed | 0.3 ± 0.2 | Mixed |
21 | 0.3 ± 0.2 | Mixed | 0.4 ± 0.3 | Mixed |
41 | 0.6 ± 0.3 | Uncompetitive | 2.1 ± 0.5 | Uncompetitive |