Table 2.
Urine protein analysis results in the three groups.
| Group | Number | Week 0 | Week 4 | Week 8 | Week 12 |
|---|---|---|---|---|---|
| NC | 8 | 0.0031 ± 0.0013 | 0.0037 ± 0.0012a | 0.0052 ± 0.0025a | 0.0056 ± 0.0020a |
| DN | 8 | 0.0033 ± 0.0011 | 0.1176 ± 0.0558b | 0.1696 ± 0.0840b | 0.1939 ± 0.0678b |
| RAPA | 8 | 0.0038 ± 0.0008 | 0.1110 ± 0.0278b | 0.1199 ± 0.0350b | 0.1250 ± 0.0313c |
| F | 0.881 | 25.237 | 20.578 | 38.971 | |
| P | 0.429 | 0 | 0 | 0 |
Note: Proteinuria is a typical clinical manifestation of diabetic nephropathy. It could be observed that proteinuria increased significantly in the DN group from 4th week compared with the results in the NC group (P < 0.05). With the development of the disease, the results of urinary protein increased significantly in the 12th week compared with the 4th week (P < 0.05), which was consistent with the characteristics of the disease. Compared with the NC group, urinary protein quantification increased significantly in the RAPA group from 4th week (P < 0.05), but decreased significantly compared with the DN group at the end of the 12th week (P < 0.05), which was related to the effect of RAPA.