Table 3.
Blood creatinine analysis results in the three groups.
| Group | Number | Week 0 | Week 4 | Week 8 | Week 12 |
|---|---|---|---|---|---|
| NC | 8 | 43.7826 ± 10.2562 | 47.1250 ± 9.7605a | 47.7500 ± 8.3109a | 51.2500 ± 5.9702a |
| DN | 8 | 41.2367 ± 8.1289 | 55.3750 ± 13.2874b | 80.8750 ± 17.1167b | 119.2500 ± 28.6394b |
| RAPA | 8 | 44.2918 ± 7.6721 | 51.7500 ± 11.2285b | 73.6250 ± 9.5310b | 100.1250 ± 10.7230c |
| F | 0.279 | 1.094 | 16.069 | 30.401 | |
| P | 0.759 | 0.353 | 0 | 0 |
Note: The persistent proteinuria can cause glomerulosclerosis, which decrease glomerular filtration rate and increased blood creatinine. In this study, we found that the blood creatinine of the DN and RAPA groups increased gradually from the 4th week compared with the NC group (P < 0.05). At the end of the 12 week, the blood creatinine of the RAPA group decreased compared with that of the DN group, which may be related to the effect of RAPA (P < 0.05).