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. 2018 Sep 10;13:2821–2832. doi: 10.2147/COPD.S172579

Figure 4.

Figure 4

Effects of the nucleosides on (A) mRNA, (B) Western blot, and (C) quantity of SIRT1, as well as (D) Western blot and (E) quantity of NF-κB/p65 in CSE-induced RAW264.7 cells.

Notes: **P<0.01, CSE-induced group vs control group (without any treatment); #P<0.05, ##P<0.01, nucleoside treatment groups (25 and 50 µg/mL) vs CSE-induced group. All the experiments were repeated three times. Data shown as mean ± SEM (n=3).

Abbreviations: CSE, cigarette smoke extract; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor-κB; NO, nitric oxide; SIRT1, silent information regulator 1.