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. 2018 Sep 10;13:2821–2832. doi: 10.2147/COPD.S172579

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© 2018 Sun et al. This work is published and licensed by Dove Medical Press Limited

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Impact of the SIRT1 antagonist EX527 on treatment effects of the nucleosides on the CSE-induced RAW264.7 cells.

Notes: (A) mRNA levels of SIRT1, TNF-α, IL-6, IL-1β, and iNOS; (B) Western blots of SIRT1, NF-κB/p65, and iNOS; (C) quantification histograms of SIRT1, NF-κB/p65, and iNOS. Study groups: 1, C: control, without any treatment; 2, CSE: CSE treatment; 3, CSE + N: CSE + nucleoside (50 µg/mL) treatment; 4, EX + CSE + N: EX527 (10 µM) + CSE + nucleosides (50 µg/mL) treatment; 5, EX + CSE: EX527 (10 µM) + CSE treatment; 6, EX: EX527 (10 µM) treatment. ^#P<0.05, CSE + N group vs CSE group; *P<0.05, C: CSE + EX + N group vs CSE + EX group.

Abbreviations: CSE, cigarette smoke extract; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-1β, interleukin-1β; IL-6, interleukin-6; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor-κB; NO, nitric oxide; SIRT1, silent information regulator 1.