Table 2.
Univariate and multivariate predictors of POAF: within the first 7 days following cardiac surgery in the LAACS studya
| Variable | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| χ2 | OR | p-value | χ2 | OR | p-value | |
| Age | 11.9 | 1.07 (95% CI 1.03–1.11) | <0.001 | 3.9 | 1.05 (95% CI 1.00–1.09) | 0.03 |
| Male gender | 0.3 | 0.80 (95% CI 0.34–1.85) | 0.60 | – | – | – |
| CHA2DS2-VASc | 6.4 | 1.33 (95% CI 1.07–1.67) | 0.01 | – | – | – |
| Beta blocker | 0.1 | 1.11 (95% CI 0.59–2.10) | 0.75 | – | – | – |
| Calcium blocker | 6.5 | 2.48 (95% CI 1.23–5.00) | 0.01 | 6.0 | 2.69 (95% CI 1.22–5.92) | 0.01 |
| RAS blocker | 1.2 | 0.70 (95% CI 0.38–1.31) | 0.27 | – | – | – |
| Statin | 0.0 | 0.99 (95% CI 0.43–2.28) | 0.97 | – | – | – |
| LAACS (randomized) | 5.7 | 0.46 (95% CI 0.24–0.87) | 0.02 | 6.3 | 0.40 (95% CI 0.19–0.82) | 0.01 |
| Surgery typeb | 7.0 | 2.37 (95% CI 1.25–4.47) | 0.01 | 4.2 | 2.11 (95% CI 1.04–4.30) | 0.04 |
Notes:
ORs for postoperative (within the first 7 days following cardiac surgery) new-onset AF (yes/no). Multivariate ORs reflect the predictors that remained significant at a 95% significance level when including all predictors with a univariate p<0.70 (to remove irrelevant parameters) in stepwise selection.
“Valve” (aortic [n=26] or mitral valve replacement [n=8]) or “vessel and valve surgery” (aortic valve replacement with CABG [n=32], aortic valve replacement with aortic repair [n=2], aortic and mitral valve replacement [n=2] or mitral valve replacement with CABG [n=3]) as compared to “vessel only” (aortic repair [n=1] or CABG [n=86]).
Abbreviations: AF, atrial fibrillation; CABG, coronary artery bypass grafting; CHA2DS2-VASc, congestive heart failure, hypertension, age (≥75 years), diabetes, stroke – peripheral vascular disease, age (≥65 years), sex category; LAACS, Left Atrial Appendage Closure with Surgery; OR, odds ratio; POAF, perioperative AF; RAS, renin–angiotensin system.