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Vascular response is impaired with age and SOD2 deficiency in isolated young (4 months old) and aged (16 months old) mouse aortic rings. Nitroglycerine (NTG) induced relaxation (% of peak PE response) of aortic rings pre-constricted with 1μmol/L phenylephrine (PE) treatment. N=6–8 mice each group. *p<0.05 vs. young WT (WT-Y) aortic rings; #p<0.05 aged SOD2 +/− (SOD-O) vs. aged WT (WT-O) aortic rings.
