Table 3:
Hazard ratios, 95% confidence intervals, and P values for 10-year risk of CVD predicted by established CVD risk factors (model A) and established CVD risk factors plus hypertensive disorders of pregnancy and parity (model B), overall and stratified by age at start of interval
| Overall | Ages 40–49 | Ages 50–59 | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Model A: Established CVD Risk Factors | ||||||
| Age, years | 1.03 (1.01, 1.05) | <0.01 | 1.01 (0.93, 1.08) | 0.89 | 0.93 (0.68, 1.27) | 0.64 |
| Age squared | 1.00 (1.00, 1.00) | 0.88 | 0.99 (0.98, 1.01) | 0.41 | 1.01 (0.99, 1.03) | 0.46 |
| Total cholesterol, mg/dL | 1.01 (1.01, 1.02) | <0.001 | 1.01 (1.00, 1.02) | <0.001 | 1.01 (1.01, 1.02) | <0.001 |
| HDL-C, mg/dL | 0.99 (0.98, 0.99) | <0.001 | 0.99 (0.98, 1.00) | 0.03 | 0.98 (0.97, 1.00) | <0.01 |
| Anti-hypertensive medication use (yes/no) | 2.06 (1.60, 2.67) | <0.001 | 2.24 (1.59, 3.14) | <0.001 | 1.76 (1.20, 2.59) | <0.01 |
| Systolic blood pressure, mm Hg | 1.02 (1.01, 1.03) | <0.001 | 1.03 (1.02, 1.04) | <0.001 | 1.01 (1.00, 1.02) | 0.06 |
| Systolic blood pressure * anti-hypertensive medication use | 0.98 (0.97, 0.99) | <0.01 | 0.96 (0.94, 0.98) | <0.001 | 1.00 (0.98, 1.02) | 0.66 |
| Current smoker (yes/no) | 2.40 (1.98, 2.92) | <0.001 | 2.41 (1.86, 3.13) | <0.001 | 2.40 (1.80, 3.20) | <0.001 |
| Diabetes (yes/no) | 1.57 (1.14, 2.17) | <0.01 | 2.06 (1.19, 3.54) | <0.01 | 1.40 (0.94, 2.09) | 0.10 |
| Model B: Established CVD Risk Factors Plus Hypertensive Disorders of Pregnancy and Parity | ||||||
| Age, years | 1.03 (1.01, 1.05) | <0.01 | 1.01 (0.93, 1.09) | 0.85 | 0.93 (0.68, 1.27) | 0.64 |
| Age squared | 1.00 (1.00, 1.00) | 0.88 | 0.99 (0.98, 1.01) | 0.41 | 1.01 (0.99, 1.03) | 0.46 |
| Total cholesterol, mg/dL | 1.01 (1.01, 1.02) | <0.001 | 1.01 (1.00, 1.02) | <0.01 | 1.01 (1.01, 1.02) | <0.001 |
| HDL cholesterol, mg/dL | 0.99 (0.98, 0.99) | <0.001 | 0.99 (0.98, 1.00) | 0.04 | 0.98 (0.97, 1.00) | <0.01 |
| Anti-hypertensive medication use (yes/no) | 2.03 (1.57, 2.63) | <0.001 | 2.19 (1.55, 3.07) | <0.001 | 1.75 (1.19, 2.58) | <0.01 |
| Systolic blood pressure, mm Hg | 1.02 (1.01, 1.03) | <0.001 | 1.03 (1.02, 1.04) | <0.001 | 1.01 (1.00, 1.02) | 0.06 |
| Systolic blood pressure * antihypertensive medication use | 0.98 (0.97, 0.99) | <0.01 | 0.96 (0.94, 0.98) | <0.001 | 1.00 (0.98, 1.02) | 0.66 |
| Current smoker (yes/no) | 2.39 (1.97, 2.90) | <0.001 | 2.39 (1.84, 3.10) | <0.001 | 2.40 (1.80, 3.19) | <0.001 |
| Diabetes (yes/no) | 1.57 (1.14, 2.17) | <0.01 | 2.06 (1.20, 3.55) | <0.01 | 1.40 (0.94, 2.08) | 0.10 |
| Nulliparous | 1.07 (0.86, 1.34) | 0.53 | 1.10 (0.81, 1.51) | 0.53 | 1.04 (0.76, 1.42) | 0.81 |
| Normotensive pregnancy and para 1 | 1.30 (1.03, 1.65) | 0.03 | 1.53 (1.11, 2.11) | 0.01 | 1.09 (0.77, 1.55) | 0.62 |
| Normotensive pregnancies and para >3 | 1.09 (0.88, 1.35) | 0.43 | 1.11 (0.82, 1.49) | 0.50 | 1.07 (0.80, 1.45) | 0.65 |
| History of HDP and para 1 | 1.15 (0.71, 1.87) | 0.58 | 1.37 (0.73, 2.56) | 0.33 | 0.91 (0.42, 1.96) | 0.81 |
| History of HDP and para 2 | 1.51 (1.11, 2.04) | <0.01 | 1.81 (1.22, 2.71) | <0.01 | 1.19 (0.74, 1.92) | 0.47 |
| History of HDP and para >3 | 0.95 (0.62, 1.47) | 0.82 | 0.84 (0.45, 1.58) | 0.60 | 1.07 (0.59, 1.96) | 0.83 |
Abbreviations: CVD: cardiovascular disease. CI: confidence intervals. HDL-C: high-density lipoprotein cholesterol. HDP: hypertensive disorder of pregnancy. HR: hazard ratio. Indicator (yes/no) variables unless otherwise noted. Reference group for hypertensive disorder of pregnancy and parity is normotensive pregnancies and para 2.