Table 5:
Net reclassification of 10-year cardiovascular disease risk into low (<5%), intermediate (5% - <10%), and high (≥10%) risk groups, comparing model A (based on established CVD risk factors) to model B (based on established CVD risk factors plus hypertensive disorders of pregnancy and parity) among women with incident CVD and those without incident CVD
| Model B: Established Risk Factors Plus Hypertensive Disorders of Pregnancy and Parity | ||||
| Categories of Predicted 10-Year Risk | ||||
| Model A: Established Risk Factors | Low Risk: | Intermediate Risk: | High Risk: | Total |
| Categories of Predicted 10-Year Risk | <5% | 5%–<10% | >10% | Reclassified |
| Women with incident CVD (n=685) | ||||
| Low Risk: <5% | ||||
| N | 669 | 4 | 0 | 4 |
| % Reclassified | --- | 0.6 | --- | 0.6 |
| Intermediate Risk: 5% - <10% | ||||
| N | 1 | 11 | 0 | 1 |
| % Reclassified | 8.3 | --- | --- | 8.3 |
| High Risk: >10% | ||||
| N | 0 | 0 | 0 | --- |
| % Reclassified | --- | --- | --- | --- |
| Women without incident CVD (n=105,545) | ||||
| Low Risk: <5% | ||||
| N | 105,293 | 60 | 0 | 60 |
| % Reclassified | --- | 0.06 | --- | 0.06 |
| Intermediate Risk: 5% - <10% | ||||
| N | 27 | 153 | 4 | 31 |
| % Reclassified | 14.7 | --- | 2.2 | 16.9 |
| High Risk: >10% | ||||
| N | 0 | 2 | 6 | 2 |
| % Reclassified | --- | 25.0 | --- | 25.0 |
Abbreviations: CVD: cardiovascular disease. Established risk factors include age, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication use, current smoking, and diabetes.
NRI = 0.004; 95% CI: -0.002, 0.010; P = 0.26. NRI for events = 0.004; 95% CI: -0.002, 0.010; P = 0.21. NRI for non-events = -0.0003; 95% CI: -0.0005, -0.0002; P = 0.0003.