Online Table 3:

Net reclassification of 10-year cardiovascular disease risk into low (<5%), intermediate (5% - <10%), and high (≥10%) risk groups, comparing model A (based on established CVD risk factors) to model B (based on established CVD risk factors plus hypertensive disorders of pregnancy and parity) among women with incident CVD and those without incident CVD at ages 40–49

	Model B: Established CVD Risk Factors Plus
	Hypertensive Disorders of Pregnancy and Parity
	Categories of Predicted 10-Year Risk
Model A: Established CVD Risk Factors	Low Risk:	Intermediate Risk:	High Risk:	Total
Categories of Predicted 10-Year Risk	<5%	5%–<10%	≥10%	Reclassified
Women with incident CVD (n=359)
Low Risk: <5%
N	355	1	0	---
% Reclassified	---	0.3	---	---
Intermediate Risk: 5%–<10%
N	1	2	0	1
% Reclassified	33.3	---	---	33.3
High Risk: ≥10%
N	0	0	0	---
% Reclassified	---	---	---	---
Women without incident CVD (n=73,693)
Low Risk: <5%
N	73,637	28	0	28
% Reclassified	---	0.04	---	0.04
Intermediate Risk: 5% - <10%
N	9	17	2	11
% Reclassified	32.1	---	7.1	39.2
High Risk: ≥10%
N	0	0	0	---
% Reclassified	—	—	—	—

Abbreviation: CVD: cardiovascular disease. Established risk factors include age, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication use, current smoking, and diabetes. NRI = -0.00003; 95% CI: -0.006, 0.007; P = 0.99. NRI for events = 0.0002; 95% CI: -0.005, 0.008; P = 0.94. NRI for non-events = -0.0003; 95% CI: -0.0004, -0.0001; P = 0.001.