Online Table 7:
Net reclassification of 10-year cardiovascular disease risk into low (<7.5%) and high (≥7.5%) risk groups, comparing model A (based on established CVD risk factors) to model B (based on established CVD risk factors plus hypertensive disorders of pregnancy and parity) among women with incident CVD and those without incident CVD at ages.50–59
Model B: Established CVD Risk Factors Plus Hypertensive Disorders of Pregnancy and Parity | |||
Categories of Predicted 10-Year Risk | |||
Model A: Established CVD Risk Factors | Low Risk: <7.5% | High Risk: ≥7.5% | Total Reclassified |
Categories of Predicted 10-Year Risk | |||
Women with incident CVD (n=326) | |||
Low Risk: <7.5% | |||
N | 322 | 1 | 1 |
% Reclassified | --- | 0.3 | 0.3 |
High Risk: ≥7.5% | |||
N | 1 | 2 | 1 |
% Reclassified | 33.3 | --- | 33.3 |
Women without incident CVD (n=31,852) | |||
Low Risk: <7.5% | |||
N | 31,807 | 9 | 9 |
% Reclassified | --- | 0.03 | 0.03 |
High Risk: ≥7.5% | |||
N | 4 | 32 | 4 |
% Reclassified | 11.1 | --- | 11.1 |
Abbreviation: CVD: cardiovascular disease. Established risk factors include age, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication use, current smoking, and diabetes. NRI = -0.00002; 95% CI: -0.007, 0.007; P = 0.99. NRI for events = 0.0001; 95% CI: -0.007, 0.008; P = 0.97. NRI for non-events = -0.0002; 95% CI: -0.0004, 0.0001; P = 0.17.