Table 1.
Clinical observations in ferrets after vaccination with monovalent B-LAIV.
| Group | B/Vic LAIV (groups 1-2) | B/Yam LAIV (groups 3-4) | Intact animals (group 7) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day | Day 0 | Day 1 | Day 2 | Day 3 | Day 0 | Day 1 | Day 2 | Day 3 | Day 0 | Day 1 | Day 2 | Day 3 |
| Body temperature (°C) | 38.4 | 38.3 | 38.7 | 38.8 | 38.7 | 38.8 | 38.9 | 38.8 | 38.5 | 38.7 | 38.6 | 38.7 |
| Activity [group Median (Q1-Q3)] | 3.0 (3.0-3.0) | 2.5 (1.0-3.0) | 2.5 (1.0-3.0) | 3.0 (3.0-3.0) | 3.0 (3.0-3.0) | 1.5 (0.0-2.0) | 2.0 (2.0-2.0) | 2.5 (2.0-3.0) | 3.0 (3.0-3.0) | 3.0 (3.0-3.0) | 3.0 (3.0-3.0) | 3.0 (3.0-3.0) |
| Respiratory symptoms [group Median (Q1-Q3)] | 0.0 (0.0-0.0) | 0.51 (0.0-1.0) | 0.51 (0.0-1.0) | 0.51 (0.0-1.0) | 0.0 (0.0-0.0) | 1.01 (1.0-1.0) | 1.01 (1.0-1.0) | 1.01 (0.0-1.0) | 0.0 (0.0-0.0) | 0.0 (0.0-0.0) | 0.0 (0.0-0.0) | 0.0 (0.0-0.0) |
Abbreviations are used here and in Tables 2–5 and Figures 1 and 2: B/Yam LAIV, monovalent LAIV based on B/60/Phuket/2013/26 (B/Yamagata lineage); B/Vic LAIV, monovalent LAIV based on B/60/Brisbane/2008/83 (B/Victoria lineage); B/Yam WT, B/Phuket/3073/2013 wild type virus (B/Yamagata lineage); B/Vic WT, B/Brisbane/60/2008 wild-type virus (B/Victoria lineage). Statistically significant differences: 1median test between groups, p≤0.05, post hoc Dunnett test, p≤0.05 (versus intact group).