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Binding interaction of the best selected compounds with the HEV-helicase active residues. The modeled protein (residues no. 1-232 corresponding to HEV-hel a.a. 963-1194) shows the interacting residues Gly13 (HEV-hel Gly975), Gly16 ((HEV-hel Gly978), Ser17 (HEV-hel Ser979), and Gly18 (HEV-hel Gly980) within the highly conserved Walker A motif.
