. 2018 Aug 30;2018:4237354. doi: 10.1155/2018/4237354

Table 4.

Effects of plasma ALT, AST, BUN, and creatinine in diabetic rats fed different doses of nano-EE after 7 weeks.

	Con	DM	Met	Nano	Nano-EE1	Nano-EE3	Nano-EE5
AST (U/L)	12.47 ± 0.78^d	20.04 ± 0.90^a	15.78 ± 1.02^bc	18.19 ± 1.14^ab	13.13 ± 0.91^cd	13.13 ± 0.74^cd	12.33 ± 0.50^d
ALT (U/L)	7.72 ± 0.69^b	14.07 ± 0.39^a	10.06 ± 0.58^b	11.17 ± 1.55^ab	11.98 ± 1.35^b	10.20 ± 0.83^b	9.01 ± 0.90^b
BUN (mg/dL)	23.58 ± 1.77^b	32.22 ± 8.46^ab	27.35 ± 2.38^ab	37.88 ± 5.60^a	27.51 ± 2.28^ab	24.20 ± 3.58^b	23.58 ± 0.61^b
Creatinine (mg/dL)	2.42 ± 0.06^bc	2.92 ± 0.20^a	2.66 ± 0.12^abc	2.73 ± 0.16^ab	2.88 ± 0.11^ab	2.18 ± 0.16^cd	1.93 ± 0.16^d

Data were shown as the mean ± SEM (n = 5 rats/group). Con: control; DM: diabetes; Met: diabetes + 200 mg/kg per day metformin; Nano: diabetes + 465 mg/kg per day per chitosan and silica; Nano-EE1: diabetes + 93 mg/kg per day EE; Nano-EE3: diabetes + 279 mg/kg per day EE; Nano-EE5: diabetes + 465 mg/kg per day EE. The values with different letters (a-b) represent significantly different (p < 0.05) as analyzed by Duncan's multiple range test.

(i) Alanine aminotransferase (ALT).

(ii) Aspartate aminotransferase (AST).