Table 1.

EPLIN-interacting proteins and potential functions.

Protein	Interaction	Function	Reference(s)
Actin	The two actin-binding domains of EPLIN cross-link and bundle actin filaments	EPLIN inhibits actin turnover and limits the dynamic remodeling of the actin cytoskeleton	7, 10, 11
α-catenin	The binding of EPLIN and α-catenin requires the N- and C-terminal regions of EPLIN and the vinculin homology (VH)3-C-terminal region of α-catenin	EPLIN links the cadherin–catenin complex to F-actin, stabilizing the adhesion belt	23
Septin 2 (Nedd5)	EPLIN is associated with Septin 2 during interphase and mitosis	EPLIN contributes to Septin 2 cleavage furrow localization during late stages of cytokinesis	29
Myosin IIb	EPLIN is associated with myosin IIb of the contractile ring	EPLIN enhances the accumulation of actin and active myosin II at the cleavage furrow during the final stages of ingression	27, 29, 30, 33, 34, 35
Supervillin	The C-terminal region of supervillin binds EPLIN	EPLIN and supervillin are concentrated at the cleavage furrow during the early stages of cytokinesis and may be required for cell division	35
Paxillin	EPLIN is localized in peripheral actin bundles at focal adhesions and formed a protein complex with paxillin	EPLIN may stabilize focal adhesions by interacting with paxillin	31, 36
ERK1/2	ERK binds and phosphorylates mouse EPLIN at Ser360, Ser602, and Ser692	EPLIN phosphorylation is required for PDGF-induced stress fiber disassembly, membrane ruffling and cell migration	37
PTEN	PTEN is associated with actin remodeling complex including EPLIN	It is unclear if EPLIN is required for the PTEN regulation of cell size checkpoint	38
PINCH-1 (Lims1)	PINCH-1 recruits EPLIN to the integrin adhesion sites in keratinocytes	Regulates the spreading and migration on collagen and fibronectin	34
Arv1	EPLIN recruits Arv1 to the cleavage furrow in early telophase	Optimizes furrow ingression during cell division	30