Table 3.
Univariable and Multivariable Competing Risk Regression for Overall Survival
| Variable | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| SHR (95% CI) | P | SHR (95% CI) | P | |
| PORT | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.54 (0.30, 0.97) | 0.04 | 0.46 (0.24, 0.88) | 0.02 |
| Age at surgery | 1.02 (0.99, 1.05) | 0.2 | 1.02 (0.99,1.05) | 0.3 |
| Charlson Comorbidity Index | 1.16 (0.91, 1.48) | 0.2 | 1.16 (0.90, 1.50) | 0.3 |
| Cardiac comorbidity | ||||
| No | 1.00 | — | — | — |
| Yes | 0.86 (0.49, 1.51) | 0.6 | ||
| Pulmonary comorbidity | ||||
| No | 1.00 | — | ||
| Yes | 0.89 (0.49, 1.63) | 0.7 | — | — |
| Preinduction tumor SUVmax | 0.99 (0.97, 1.01) | 0.4 | — | — |
| Pneumonectomy | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 3.32 (1.00, 11.01) | 0.05 | 1.88 (0.53, 6.61) | 0.3 |
| Lymphovascular invasion | ||||
| No | 1.00 | — | ||
| Yes | 1.20 (0.64, 2.26) | 0.6 | — | — |
| Tumor response grade | ||||
| <90% | 1.00 | — | ||
| >90% | 0.89 (0.21, 3.72) | 0.9 | — | — |
| Tumor pathologic subtype | ||||
| Squamous, large, other | 1.00 | — | ||
| Adenocarcinoma | 0.62 (0.27, 1.44) | 0.3 | — | — |
| Pathologic stage (yp) | ||||
| ypIIIA | 1.00 | — | 1.00 | — |
| ypIIIB | 1.80 (0.92, 3.52) | 0.087 | 1.64 (0.68, 3.92) | 0.3 |
| No. N2 nodal stations involved | ||||
| Single | 1.00 | — | 1.00 | — |
| Multiple | 2.37 (1.28, 4.37) | 0.006 | 2.77 (1.25, 6.13) | 0.01 |
| Adjuvant systemic therapy | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.76 (0.39, 1.51) | 0.4 | 0.55 (0.24,1.19) | 0.1 |
PORT = postoperative radiotherapy; SHR = subdistribution hazard ratio; SUVmax = maximum standardized uptake value.