Table 3.

Uni- and multivariate Cox regression models for overall survival (OS) performed in the DDR^on group (left columns) and in the DDR^off group (right columns).

		DDRon				DDRoff
		Univariate Cox		Multivariate Cox		Univariate Cox		Multivariate Cox
		regression model		regression model		regression model		regression model
		HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
PD-L1-TCs	Positive vs Negative	1.61 (0.73–3.55)	0.237	2.56 (1.06–6.16)	0.036	0.44 (0.19–1.00)	0.051	0.41 (0.17–0.96)	0.039
Stage	Metastatic vs locally advanced	1.12 (0.50–2.47)	0.787	—	—	1.58 (0.78—3.17)	0.201	—	—
N° of metastatic sites	2—3 vs 1	1.98 (0.80—4.95)	0.141	—	—	1.85(0.91—3.73)	0.088	2.52 (1.18—5.39)	0.017
Taxanes	Yes vs No	0.62 (0.26—1.46)	0.274	—	—	0.72 (0.36—1.46)	0.368	—	—
Second-line chemotherapy	Yes vs No	0.32 (0.13—0.78)	0.012	0.23 (0.09—0.60)	0.003	0.50 (0.24—1.03)	0.062	0.44 (0.21—0.96)	0.039

^*Backward stepwise exclusion.