Correlations between MVs highly expressing ectoenzymes and clinical parameters of MM patients. MM patients were split in two groups on the basis of clinical parameters, and the percentage of MVs highly expressing CD203a(PC-1), CD38, CD73, CD157 and CD39 was compared between these two groups. Panel A shows the analysis of the percentage of MVs highly expressing ectoenzymes in MM patients with ISS Stage I-II (white columns) or Stage III (grey columns). Panel B shows the analysis of the percentage of MVs highly expressing ectoenzymes in MM patients with a percentage of plasma cells below (white columns) or above (grey columns) 10% of total BM cells. The analysis of the correlation between percentage of MVs highly expressing CD38 or CD157 and the percentage of plasma cells in the BM is shown in Panel C and Panel D, respectively.