Figure 4.

S100A4 deficiency decreases colorectal tumorigenesis. (A) Schematic overview of the experimental CAC model using S100A4^−/− and WT control littermates. (B) Representative photographs of the colon from S100A4^−/− and WT mice on day 120 of age. (C) The tumor number of the entire colon was counted, and each tumor size was measured. Total tumor incidence and (D) incidence of tumors over 4 mm² in S100A4^−/− and WT mice are shown. (E) The colon sections of CAC were stained with H&E, S100A4 and Ki67. Representative images are shown. (F) The number of S100A4⁺ cells in tumors per HPF (×200) and (G) percentages of Ki67⁺ cells in tumors are shown. *P < 0.05, **P < 0.01.