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. 2018 Aug 28;7:e36607. doi: 10.7554/eLife.36607

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© 2018, Pautrat et al

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Figure 3. — (A) Phasic responses. Peristimulus histograms showing individual cases of different types of phasic noxious-evoked responses in the STN. The dashed vertical line indicates the onset time of the nociceptive footshock. The n associated with each histogram indicates the number of cases exhibiting that class of response; total n = 98. (B) Tonic responses. Peristimulus histograms showing individual cases of decreased (left) and increased (right) STN baseline firing rate with the nociceptive stimulation. Histograms of the group mean data (±standard error of the mean [SEM]) during the sham (dark gray) and nociceptive (light gray) stimulation. The histograms show a significant increase or decrease of the baseline firing rate in the up (p<0.001) and down groups (p<0.001), respectively, and no effect of the no change group (p=0.1272). Note the higher baseline firing rate of the down cells during the sham stimulation compared to that of the up groups (p<0.05).