Table 2. Nociceptive responses in the subthalmic nucleus, superior colliculus and parabrachial nucleus.
| Microinjection of muscimol in the superior colliculus | ||||
|---|---|---|---|---|
| Superior colliculus | Subthalamic nucleus | |||
| Pre muscimol | Post muscimol | Pre muscimol | Post muscimol | |
| Latency | 9 ± 0.8 ms | 7.60 ± 0.68 ms | 25.33 ± 5.27 ms | 28.38 ± 7.75 ms |
| Duration | 19.62 ± 5.00 ms | 14 ± 3.03 ms | 176.13 ± 60.37 ms | 135.74 ± 50.19 ms * |
| Amplitude | 322.29 ± 58.16 Hz | 125.00 ± 26.22 Hz * | 15.61 ± 3.29 Hz | 14.4 ± 2.44 Hz |
| Magnitude | 140.20 ± 28.01 Hz | 45.01 ± 9.16 Hz * | 10.21 ± 1.99 Hz | 7.24 ± 1.41 Hz |
| Baseline FR no footshock | 18.27 ± 2.19 Hz | — | 4.37 ± 0.8 Hz | - |
| Baseline FR footshock | 20.79 ± 2.66 Hz | 7.69 ± 3.00 Hz * | 6.06 ± 1.48 Hz | 6.45 ± 1.38 Hz |
| Microinjection of muscimol in the parabrachial nucleus | ||||
|---|---|---|---|---|
| Parabrachial nucleus | Subthalamic nucleus | |||
| Pre muscimol | Post muscimol | Pre muscimol | Post muscimol | |
| Latency | 11.55 ± 1.35 ms | 19.00 ± 2.48 ms * | 24.54 ± 3.13 ms | 18.43 ± 1.73 ms |
| Duration | 26.45.12 ± 3.85 ms | 14 ± 3.49 ms * | 98.00 ± 27.35 ms | 45.75 ± 12.04 ms * |
| Amplitude | 146.97.42 ± 23.66 Hz | 83.26 ± 17.02 Hz * | 26.98 ± 5.72 Hz | 17.18 ± 3.26 Hz * |
| Magnitude | 45.16 ± 7.45 Hz | 23.70 ± 4.57 Hz * | 10.31 ± 2 Hz | 6.65 ± 1.44 Hz * |
| Baseline FR no footshock | 24.25 ± 1.97 Hz | — | 5.89 ± 0.49 Hz | — |
| Baseline FR footshock | 20.55 ± 2.42 Hz | 14.15 ± 2.76 Hz | 5.50 ± 0.71 Hz | 5.39 ± 0.57 Hz |
Mean ± SEM - * statistically different from pre-muscimol measure.
Abbreviations: cp, cerebral peduncle; IS, injection site; lPBN, lateral parabrachial nucleus; mPBN, medial parabrachial nucleus; scp, superior cerebral peduncle; STN, subthalamic nucleus.
Note: the amplitude of the response is the maximum amplitude during the response and the magnitude of the response is the mean number of single multi-unit events between response onset and offset minus the baseline mean.