Table 1.

Categories of Interactions among Chemical Probes of E. coli under Nutrient Stress

Category	Interactions
	Synergy	Antagonism	Total
HK probesa	18	39	57
NS probesb	22	19	41
HK probes and NS probesc	41	47	88
Total	81	105	186

^aHK probes, housekeeping-function probes, refer to 27/45 compounds that target housekeeping functions (Data S1). Interactions belonging to the HK probes category involve 49 antibiotic-antibiotic and 8 lamotrigine-antibiotic combinations.

^bNS probes, nutrient synthesis probes, refer to 18/45 compounds that target nutrient synthesis functions (Data S1). Interactions belonging to the NS probes category involve combinations between these 18 nutrient synthesis probes.

^cInteractions belonging to the HK probes and NS probes category involve interactions between a housekeeping-function probe and a nutrient synthesis probe.