Figure 10.

In vivo antitumor efficacy of MSC NPs.

Notes: (A) Kaplan–Meier survival curve; (B) median survival time *(P<0.05); (C) H&E sections of tumor tissues from C6 glioma-bearing rats. Ptx-PLGA NPs, MSCs-Ptx, and MSCs-NPs with a dose of 1 µg Ptx-equivalent/kg, as well as saline and MSC controls, were injected contralaterally 1 week after tumor implantation. On the seventh day after therapeutic injection, tumor masses were stained with H&E for histopathology evaluation.

Abbreviations: Ptx-PLGA NPs, paclitaxel poly(d,l-lactide-co-glycolide) nanoparticles; MSC, mesenchymal stem cell.