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. 2018 Sep 7;13:5231–5248. doi: 10.2147/IJN.S167142

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Osteogenic and adipogenic differentiation of MSCs treated with 8 ng/mL Ptx-PLGA NPs for 8 hours.

Notes: (A) Osteogenic differentiation of MSC NPs. Calcium-nodule deposits were stained with alizarin red. Undifferentiated MSCs were set as the negative control. Quantification of ALP was performed in the early stage of osteogenic differentiation. (B) Adipogenic differentiation of MSC NPs. Neutral lipid vacuoles were stained with oil red O (400×). The fraction of positive cells was compared with that of untreated MSCs.

Abbreviations: MSCs, mesenchymal stem cells; Ptx, paclitaxel; PLGA, poly(d,l-lactide-co-glycolide); NPs, nanoparticles.