Table 2.

Laboratory findings in PFIC subtypes. (N= normal, H= high/elevated, L= low/depleted)

	PFIC type 1	PFIC type 2	PFIC type 3
Serum GGT	N	N	H
Serum direct bilirubin	H	H	H
Serum bile acids	H(++)	H(+++)	H(+)
Serum ALP	H	H	H
Serum ALT	H	H	H
Biliary phospholipids	N	N	L
Serum5′-nucleotidase	H	H	H
Serum AFP	N	H	N

Abbreviations: PFIC, progressive familial intrahepatic cholestasis; AFP, alphafetoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; GGT, gamma glutamyl transferase.