Table 4.

Liver biopsy, electron microscopy features and treatment modalities for PFIC subtypes

	PFIC type 1	PFIC type 2	PFIC type 3
Histology	Intracanalicular cholestasis, bile duct proliferation at the late phase	Bile duct proliferation at the late phase, lobular and portal fibrosis	Extensive bile duct proliferation and periportal fibrosis
Bile on electronmicroscopy	Granular called “Byler bile”	Amorphous or filamentous	_
Therapy	UDCA biliary diversion liver transplantation	UDCA biliary diversion liver transplantation	UDCA liver transplantation

Abbreviations: PFIC, progressive familial intrahepatic cholestasis; UDCA, ursodeoxycholic acid.