Table 1.

Comparison of the effect of 114 ug/L selenium on overall prostate cancer, high-grade/advanced prostate cancer, and type 2 diabetes in SELECT and Mendelian randomization

Outcome	SELECT HR (95% CI)	Mendelian randomization OR (95% CI)
Overall prostate cancer	1.04 (0.91 to 1.19)	1.01 (0.89 to 1.13)
High-grade/advanced prostate cancer*	1.21 (0.97 to 1.52)	1.21 (0.98 to 1.49)
Type 2 diabetes	1.07 (0.87 to 1.18)	1.18 (0.97 to 1.43)

^*“High-grade prostate cancer” pertains to SELECT results, and “advanced prostate cancer” pertains to Mendelian randomization results. CI = confidence interval; HR = hazard ratio; OR = odds ratio.