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. 2018 Feb 22;110(9):1019–1029. doi: 10.1093/jnci/djy003

Figure 3.

Figure 3.

Hematoxylin and eosin (H&E), immunohistochemistry, and immunofluorescence staining of metastatic anaplastic thyroid cancer (8505C) xenograft and normal organs (heart, liver, and kidney) in mice treated with CYT-21625, CYT-6091, paclitaxel, and vehicle. A) CD34 expression in intratumoral blood vessels (arrows), (B) H&E staining of normal organs (arrows indicate gold nanoparticles deposit), (C) CD34 expression in vascular endothelium of normal organs (arrows), (D) the extravasation of fibrinogen in 8505C xenografts (arrows) and in (E) normal organs of mice treated with CYT-6091 and CYT-21625 (Merge (DAPI+Anti-fibrinogen)), (F) proliferating cell nuclear antigen in 8505C and FTC-133 xenografts, and (G) cleaved caspase-3 expression in 8505C and FTC-133 xenografts. The boxes in (A) represent the interquartile range contaning the middle 50% of the data. The lines across the box plot represent the median. The error bars from the upper and lower ends of the boxes represent 1.5 times the interquatile range. Two-sided analysis of variance with post hoc tests was used to compare the immunohistochemistry scores. Scale bars = 50 µm.