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. 2018 Feb 22;110(9):1019–1029. doi: 10.1093/jnci/djy003

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Published by Oxford University Press 2018. This work is written by US Government employees and is in the public domain in the US.

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Figure 4. — In vivo evaluation of biodistribution of CYT-21625 by computed tomography (CT) and 18F-FDG positron emission tomography (PET) scan. CT shows increased gold particle density in the pancreatic region (circle) in the multiple endocrine neoplasia type 1 gene knock-out mice treated with CYT-6091 and CYT-21625 at 24 hours postinjection (top), but not in the mice treated with paclitaxel and vehicle control (bottom). 18F-FDG PET images demonstrate pancreatic neuroendocrine tumor location in the midabdominal area, corresponding with the area where gold particles deposited. CT = computed tomography; PET = positron emission tomography.