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Synthesis scheme for multivalent PGA–OA conjugates.
Notes: (a) DMTMM and AEM; (b) dialysis; and (c) thiol-OA. The multivalent conjugate is a random copolymer composed of unconjugated monomers (x repeat units) and aptamer conjugates (y repeat units).
Abbreviations: AEM, N-aminoethyl maleimide; DMTMM, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate; OA, oligonucleotide aptamer; PGA, polyglutamic acid.
