Table3:

Risk factors of death patients among HIV-TB co-infected patients with baseline CD4≤50 cells/µl comparing those initiated on Early or Delayed ART

Characteristics		Incidence/100	Unadjusted (weighted)		Adjusted (weighted)
	Cases/Person	person years	HRs ( 95% CI)	p-values	HRs (95% CI)	p-values
	years	(95% CI)
Overall	58/178	32.46(23.6–45.7)
Study
Delayed; CrAg-N	16/94	16.61(10–29.3)	Ref
Delayed; CrAg-P	13/9	146.51(63.5–373.7)	6.28(2.6–15.3)	<0.001	4.78(2.2–10.5)	<0.001
Early; CrAg-N	28/69	39.41(26.1–61)	2.07(1.1–3.9)	0.025	1.95(1.0–3.9)	0.054
Early; CrAg-P	3/8	40.56(15.3–122.9)	2.28(0.8–6.6)	0.128	2.78(1.0–7.9)	0.053
Gender
Female	30/91	33.07(22.6–49.6)	Ref		Ref
Male	28/88	31.84(18.9–57.7)	0.95(0.5–1.8)	0.879	0.59(0.3–1.1)	0.082
Age (years)
18–24	14/15	93.4(41.1–246.1)	Ref		Ref
25–34	17/89	18.75(11.6–31.7)	0.21(0.1–0.5)	<0.001	0.21(0.1–0.5)	<0.001
35–44	20/60	32.25(18.2–62.7)	0.38(0.2–0.9)	0.026	0.32(0.2–0.6)	<0.001
45–75	9/16	54.74(26.4–122.7)	0.61(0.2–1.6)	0.324	0.62(0.2–1.6)	0.314
Haemoglobin (g/dL)
0 – 8.0	32/70	45.61(28.6–76.7)	Ref		Ref
8.1 – 15.8	27/109	24.08(16–37.6)	0.56(0.3–1.0)	0.060	0.74(0.4–1.3)	0.287
WHO_Stage
III	26/109	23.36(15.4–36.9)	Ref		Ref
IV	33/69	46.86(29.6–77.9)	1.99(1.1–3.6)	0.024	1.92(1.1–3.3)	0.017
Extra pulmonary
TB*
No	29/116	24.4(16.5–37.4)	Ref
Yes	30/62	47.54(29.2–82.1)	1.92(1.1–3.5)	0.033
TB-IRIS
Negative	46/133	34.09(23.9–49.8)	Ref
Positive	13/46	27.77(12.7–73.7)	0.86(0.4–1.9)	0.706

Delayed=ART initiation delayed beyond 21 days; Early=ART initiation within 21 days

Results presented are weighted using stabilised inverse probability weights

HR=hazard ratio, CI= confidence intervals; CrAg -P = positive cryptococcal antigen test; CrAg-N=negative cryptococcal antigen test; CI=confidence interval; TB-IRIS=tuberculosis immune reconstitution inflammatory syndrome; ART= Antiretroviral therapy

^*Extra Pulmonary TB is collinear with WHO-Staging so it is excluded from the multivariate analysis