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. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Int J Hyperthermia. 2018 Apr 16;34(8):1337–1350. doi: 10.1080/02656736.2018.1446221

Anti-tumor effect of laser immunotherapy (LIT) in treating cutaneous squamous cell carcinoma (cSCC) in SKH-1 mice. (A) Temperature in tumor tissue during laser treatment. Left: Thermographic image showing the temperature of the tumor in one mouse with 808-nm laser illumination. Right: The temperature increase curve of the tumors with 808-nm laser illumination. (B) Tumor volume changes in different treatment groups. Statistical analysis for tumor volume changes was performed by t-test (day 27: Laser, or LIT group vs. Control group,*p < 0.05; Day 60: LIT group vs. Laser group, ##p < 0.01). (C) Representative photographs of mice at different times after treatments. (D) Survival rates of cSCC tumor bearing mice in different treatment groups.

Anti-tumor effect of laser immunotherapy (LIT) in treating cutaneous squamous cell carcinoma (cSCC) in SKH-1 mice. (A) Temperature in tumor tissue during laser treatment. Left: Thermographic image showing the temperature of the tumor in one mouse with 808-nm laser illumination. Right: The temperature increase curve of the tumors with 808-nm laser illumination. (B) Tumor volume changes in different treatment groups. Statistical analysis for tumor volume changes was performed by t-test (day 27: Laser, or LIT group vs. Control group,*p < 0.05; Day 60: LIT group vs. Laser group, ##p < 0.01). (C) Representative photographs of mice at different times after treatments. (D) Survival rates of cSCC tumor bearing mice in different treatment groups.