3.
探究开胸后肺切除前行胸腔冲洗液细胞学检查预后意义的相关研究
Studies demonstrating the prognostic significance of pleural lavage cytology immediately after thoracotomy and before lung resection
| Author, ref. number, year, type of study | Patient group | Outcomes: survival rate | Other results or comments |
| pre-PLC: pleural lavage cytology before lung resection or immediately after thoracotomy; post-PLC: pleural lavage cytology after lung resection; OS: overall survival; RFS: Recurrence-free survival. | |||
| Shintani et al[8] (2009) Prospective study | Total number of patients: 1, 271 Patients with positive PLC before lung resection: 67 (5.3%) | Five-year survival in pre-PLC positive patients was 44.1% compared to 58.3% in pre-PLC negative patients (P=0.039, 4) | PLC before lung resection cannot be used as an independent prognostic factor. |
| Taniguchi et al[13] (2009) Prospective study | Total number of patients: 296 Patients with positive PLC after thoracotomy: 14 (4.7%) | 5-year survival rate for negative PLC vs positive PLC after thoracotomy: 72% vs 45% (P=0.047) | A significant correlation was found between PLC after thoracotomy and T factor.PLC after thoracotomy is not an independent prognostic factor. |
| Kawachi et al[21] (2009) Retrospective study | Total number of patients: 563 Patients with positive pre-PLC: 41 (7.2%) | Patients positive for pre-PLC had significantly worse survival than pre-PLC negative patients (P＜0.000, 1) | The incidence of intrathoracic recurrence was significantly higher in pre-PLC positive patients. Positive pre-PLC was found to be an independent prognostic factor. |
| Aokage et al[14] (2010) Prospective study | Total number of patients: 2, 178 Patients with positive pre-PLC: 65 (3.0%) | The 5-year survival rate was 37% in 65 patients without dissemination but with a positive pre-PLC result, which was significantly higher than 12% in 86 patients with dissemination (P=0.002) | Pre-PLC proved to be a strong independent prognostic factor, but was of less use in clinical practice compared with post-PLC. |
| Kaneda et al[18] (2012) Retrospective study | Total number of patients: 3, 231 Patients with positive pre-PLC: 148 (4.58%) | Survival curves were significantly worse (P < 0.001) in the pre-PLC positive group | A positive pre-PLC result was found to be a poor prognostic indicator. The incidence of recurrence with pleuritis carcinomatosa was significantly higher in the pre-PLC positive group. |
| Nakao et al[12] (2015) Retrospective study | Total number of patients:1, 572 Patients with positive pre-PLC: 56 (3.6%) | Recurrence was observed more frequently (P < 0.001) and the rate of pleural recurrence at the initial site was higher (P < 0.001) in pre-PLC positive patients. | Positive pre-PLC had the significant prognostic effect in surgically resected NSCLC patients. However, it is not a contraindication for surgical resection and should be classified as pT3. |
| Tomizawa et al[20] (2016) Retrospective study | Total number of patients: 754 Positive pre-PLC immediately after thoracotomy: 38 (5.1%) | The 5-year OS of patients with positive PLC was significantly shorter than that of those with negative PLC and pT1 (P＜0.000, 1) or negative PLC and pT2 (P＜0.000, 1) and almost overlapped with that of those with negative PLC and pT3 disease (P=0.601) | Positive PLC was an independent prognostic factor in patients with resected NSCLC. Patients with positive PLC should be staged as pT3. |
| Shoji et al[34] (2016) Prospective study | Total number of patients: 700 Positive pre-PLC immediately after thoracotomy: 58 (8.2%) | The 5-year OS of patients with positive pre-PLC was significantly worse than those with negative pre-PLC (P=0.000, 1). The RFS was similarly better for patients with negative post-PLC status regardless of pre-PLC findings (not significant). | Post-PLC status but not pre-PLC status together with pathologic N factor and pathologic stage, was identified as an independent factor for poor prognosis (P=0.004, 0). |